The Gabon international will miss the clash due to “personal family reasons” following missing out on the FA Cup defeat at the same venue last week.
English outlet Mirror have reported Aubameyang is not part of the Gunners squad to face The Saints tonight, leaving Gabriel Martinelli and Frenchman Alexandre Lacazette leading the attack.
Spaniard Dani Ceballos should be back in contention following a calf complaint, with a similar injury almost certainly keeping defender Pablo Mari out.
Ryan Bertrand and Kyle Walker-Peters will be absent for Ralph Hasenhüttl’s men. Bertrand is serving a one-match ban, while Walker-Peters suffered a minor injury in training.
Forward Nathan Redmond is fit to make the team sheet following a groin problem, with Oriol Romeu expected to be out at least until the weekend.
Arsenal’s defence of FA Cup ended at the hands of Southampton on Saturday, January 23 Gabriel’s first-half own goal condemned them to a 1-0 defeat.
Southampton took the lead in the 24th minute when Kyle Walker-Peters drilled a low cross into the box, which was met by Gabriel, who unintentionally slotted it past his keeper Bernd Leno.